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However in this case, the presence of this PTPN2 SNP causes areduction in both PTPN2 expression and pSTAT5, but with the same result, that being non-responsiveness to IL-2 by Tregs during the inflammatory response in the pancreas.
Gap junc-tions are important in tissues in which activity of adjacentcells must be coordinated, such as epithelia engaged in fluidand electrolyte transport, vascular and intestinal smoothmuscle, and heart muscle.
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A measure thatappears to more closely approximate oxygencost of breathing or energy expenditure of themuscles is the pressure–time product (PTP).